Tissue Repair Technologies Limited

Our Science

The science and discoveries that have led to the founding of TRT are documented in a large number of scientific publications and patents. A selection of these publications are referenced on this page.

Information describing and illustrating the role and action of MSF and its derivatives can be accessed through this link


Bennett SP, Griffiths GD, Schor AM, Leese GP, Schor SL (2003). The use of growth factors in the treatment of chronic diabetic foot ulcers. Br J Surg 90:133-146.

Ellis IR, Jones SJ, Staunton D, Vakonakis I, Norman DG, Potts JR, Milner CM, Meenan NA, Raibaud S, Ohea G, Schor AM, Schor SL (2010a). Multi-factorial modulation of IGD motogenic potential in MSF (migration stimulating factor). Exp Cell Res. 316:2465-2476.

Kay RA, Ellis IR, Jones SJ, Perrier S, Florence M, Schor AM, Schor SL (2005). The expression of MSF, a potent onco-fetal cytokine, is uniquely controlled by 3'UTR-dependent nuclear sequestration of its precursor mRNA. Cancer Res. 65: 10742-10749.

Keatch RP. Schor AM, Vorstius JB, Schor SL (2012). Biomaterials in regenerative medicine: engineering to recapitulate the natural. Current Opinion in Biotechnology 23:579-582.

Schor A.M, Schor SL (2010). Angiogenesis and tumour progression: migration-stimulating factor as a novel target for clinical intervention. Eye. 24:450-458.

Schor SL, Ellis I, Banyard J, Schor AM (1999). Motogenic activity of the IGD amino acid motif. J Cell Sci. 112:3879-3888.

Schor SL, Ellis IR, Jones SJ, Baillie R, Seneviratne K, Clausen J, Motegi K, Vojtesek B, Kankova K, Furrie E, Sales MJ, Schor AM, Kay RA (2003). Migration Stimulating Factor (MSF): A genetically-truncated fibronectin isoform expressed by carcinoma and tumor-associated stromal cells. Cancer Res. 63:8827-8836.

Schor SL, Ellis IR, Jones SJ, Woolston AM, Schor AM. (2012) Bi-stable epigenetic switch in MSF expression is regulated by the concerted signalling of TGF-beta1 and the extracellular matrix.. Int J Cancer. 130:2024-2032.

Schor SL, Schor AM, Keatch RP, Belch JJF (2005). Role of matrix macromolecules in the aetiology and treatment of chronic ulcers. In The Wound Management Manual (ed. BY Lee). McGraw Hill, New York. pp109-121.

Shpiro N, Ellis IR, Dines TJ, Schor AM, Schor SL, Norman DG, Marquez R (2005). Synthesis of an IGD peptidomometic with motogenic activity. Mol Biosystems 1:318-320.

Vakonakis I, Staunton D, Ellis IR, Sarkies P, Flanagan A, Schor AM, Schor SL, Campbell ID (2009). Motogenic sites in human fibronectin are masked by long range interactions. J. Biol. Chem. 284:15668-15675.

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